A complete of three % of Lively material is excreted in urine as unchanged active compound. Tapentadol is Also metabolised to N-desmethyl tapentadol (thirteen %) by CYP2C9 and CYP2C19 also to hydroxy tapentadol (2 %) by CYP2D6, which can be even further metabolised by conjugation. Thus, active substance metabolism mediated by cytochrome P450 progra